Olive oil extract may help prevent obesity and diabetes

...As Well As Providing Other Protective-Health Benefits...

An extract from extra-virgin olive oil may stimulate the function of mitochondria in cells, and prevent diseases associated with dysfunction like diabetes and obesity, according to a new study.

Results of a cell study indicate that hydroxytyrosol may influence gene expression, which would influence mitochondrial function. The mitochondria are the 'power plants' of the cell, generating chemical energy by producing adenosince triphosphate (ATP), the body's energy currency. The researchers investigated effects of hydroxytyrosol that stimulate mitochondrial biogenesis and promote mitochondrial function in fat cells.

"Because mitochondrial loss and dysfunction are closely related with obesity and diabetes, these results suggest that supplement with olive oil (source of hydroxytyrosol) may have beneficial effects on preventing obesity and diabetes," the researchers explained. The results are published in the Journal of Nutritional Biochemistry.

Mediterranean Diet Benefits...
It's well-known the Mediterranean diet has been associated with a lower incidence of certain cancers and of cardiovascular disease, which is the most common and serious complication of diabetes.

Since Olive oil is the principal source of fa ts in the Mediterranean diet, and hydroxytyrosol is considered to be one of the most potent constituents of its therapeutic nutritional efficacy. They hypothesised that the Mediterranean diet or supplementation with HT (hydroxytyrosol) could stimulate mitochondrial function and prevent diabetes and obesity-related mitochondrial dysfunction, thus reducing the risk of cardiovascular disease.

Study Details...
The researchers tested the effects of different concentrations of hydroxytyrosol, ranging from 0.1 to 10 micromoles per litre, on the expression of proteins linked to mitochondrial function on fat cells. "In the present study, we showed that hydroxytyrosol over the concentration range of 0.1-10 micromoles per litre stimulated the protein expression of [peroxisome proliferator-activated receptor (PPAR) coactivator 1 alpha (PPARGC1-alpha)] - the central factor for mitochondrial biogenesis," wrote the researchers.

"We showed that hydroxytyrosol is a nutrient that effectively stimulates mitochondrial biogenesis and function," they added.

"This mitochondrial targeting property may provide a possible mechanism for the efficacy of the Mediterranean diet for lowering the risk of cardiovascular disease and also suggests that hydroxytyrosol may be used as a therapeutic intervention for preventing type-2 diabetes and obesity," they concluded.

Source: Journal of Nutritional Biochemistry


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